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Home - Products - Proteasome/Ubiquitin - E3 Ubiquitin Ligase - cIAP1 E3 ligase inhibitor D19-14

cIAP1 E3 ligase inhibitor D19-14

CAS No. ——

cIAP1 E3 ligase inhibitor D19-14( cIAP1 inhibitor D19-14 )

Catalog No. M17008 CAS No. ——

cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro.

Purity : >98% (HPLC)

COA Datasheet HNMR HPLC MSDS Handing Instructions
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Biological Information

  • Product Name
    cIAP1 E3 ligase inhibitor D19-14
  • Note
    Research use only, not for human use.
  • Brief Description
    cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro.
  • Description
    cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro; D19-14 is more potent in inhibiting the proliferation of cancer cells than D19, D19-14 exhibits acceptable pharmacokinetics properties in vivo, effectively decreases the levels of c-MYC protein in tumors in cancer xenograft model.
  • In Vitro
    ——
  • In Vivo
    ——
  • Synonyms
    cIAP1 inhibitor D19-14
  • Pathway
    Proteasome/Ubiquitin
  • Target
    E3 Ubiquitin Ligase
  • Recptor
    E3 Ubiquitin Ligase
  • Research Area
    ——
  • Indication
    ——

Chemical Information

  • CAS Number
    ——
  • Formula Weight
    385.456
  • Molecular Formula
    C18H15N3O3S2
  • Purity
    >98% (HPLC)
  • Solubility
    ——
  • SMILES
    ——
  • Chemical Name
    (E)-2-((2-(5,6-dimethoxybenzo[d]thiazol-2-yl)hydrazono)methyl)benzo[b]thiophen-3-ol

Shipping & Storage Information

  • Storage
    (-20℃)
  • Shipping
    With Ice Pack
  • Stability
    ≥ 2 years

Reference

1. Li H, et al. Proc Natl Acad Sci U S A. 2018 Sep 4. pii: 201807711.
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