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cIAP1 E3 ligase inhibitor D19-14
CAS No. ——
cIAP1 E3 ligase inhibitor D19-14( cIAP1 inhibitor D19-14 )
Catalog No. M17008 CAS No. ——
cIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro.
Purity : >98% (HPLC)
COA
Datasheet
HNMR
HPLC
MSDS
Handing Instructions
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Biological Information
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Product NamecIAP1 E3 ligase inhibitor D19-14
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NoteResearch use only, not for human use.
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Brief DescriptioncIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro.
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DescriptioncIAP1 E3 ligase inhibitor D19-14 (cIAP1 inhibitor D19-14) is an improved analog of D19, demonstrates significantly increased ability to inhibit cIAP1 autoubiquitination and reduce protein levels of c-MYC in vitro; D19-14 is more potent in inhibiting the proliferation of cancer cells than D19, D19-14 exhibits acceptable pharmacokinetics properties in vivo, effectively decreases the levels of c-MYC protein in tumors in cancer xenograft model.
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In Vitro——
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In Vivo——
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SynonymscIAP1 inhibitor D19-14
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PathwayProteasome/Ubiquitin
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TargetE3 Ubiquitin Ligase
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RecptorE3 Ubiquitin Ligase
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Research Area——
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Indication——
Chemical Information
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CAS Number——
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Formula Weight385.456
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Molecular FormulaC18H15N3O3S2
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Purity>98% (HPLC)
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Solubility——
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SMILES——
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Chemical Name(E)-2-((2-(5,6-dimethoxybenzo[d]thiazol-2-yl)hydrazono)methyl)benzo[b]thiophen-3-ol
Shipping & Storage Information
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Storage(-20℃)
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ShippingWith Ice Pack
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Stability≥ 2 years
Reference
1. Li H, et al. Proc Natl Acad Sci U S A. 2018 Sep 4. pii: 201807711.
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